Unless my biology is even more out of date than I thought, there is no reason why an inter species cross (F1 hybrid) cannot occur, though such crosses, fortunately, are rare, and there are a number of examples among mammals, such as tigrons and ligers (oh my!) and mules and hinnies where the F2 generation appears to thrive. Usually, the F2 generation is sterile, and I have never known of an F2 to F2 cross that has been recorded as having offspring. Sometimes, as in some fish, a cross back to the F1 generation may produce offspring. Indeed, the ability to produce fertile offspring is a rough and ready way (certainly prior to modern advances in genetics) to differentiate between different species and different subspecies. I have seen accidental crosses among different species of the same genus of fish (specifically, Cichlosoma) and their owners were sure that they were going to make a fortune with their new "creation", but they were pathetic creatures (always the fish and quite often the breeders) and sterile.
Any thoughts on this, Christian?